San Francisco star defensive end Nick Bosa tore the ACL in his right knee and will miss the rest of the season.

Quarterback Brock Purdy is highly unlikely to start for the San Francisco 49ers on Sunday because of a toe injury.

San Francisco 49ers quarterback Brock Purdy is a "long shot" to play against the New Orleans Saints on Sunday due to a toe injury.

San Francisco 49ers star Christian McCaffrey is questionable for the season opener after injuring his calf at practice.

Christian McCaffrey has been a standout at the San Francisco 49ers' training camp, remaining healthy after missing most of last season because of injuries.

The San Francisco 49ers have agreed to acquire receiver Skyy Moore from the Kansas City Chiefs.

The San Francisco 49ers have given receiver Deebo Samuel permission to seek a trade, according to a person familiar with the situation.

Deebo Samuel called for the ball more often this week on social media.

Joshua Karty hit a 37-yard field goal with 2 seconds to play, and the Los Angeles Rams staged a spectacular late rally for a 27-24 victory over the San Francisco 49ers.

Jauan Jennings’ historic Super Bowl milestone will turn into only a footnote after his San Francisco 49ers lost the game.

Jimmy Garoppolo threw one touchdown pass and ran in for a score, leading the San Francisco 49ers to a 17-11 victory over the Philadelphia Eagles.