What started out as a major crash resulting in a total freeway shutdown early Thursday morning has ended with the roadway reopened, as Houston police continue to investigate how it all went down.

A multi-vehicle crash on the East Freeway Monday night claimed one woman’s life and sent three other drivers to a hospital.

Harris County deputies said the 18-wheeler was not hauling anything when a Union Pacific train hit the big truck near Klein Oak High School early Tuesday morning. No injuries were reported.

Investigators said the driver was speeding with their hazards on when their vehicle left the roadway and hit a barrier before crashing into the 18-wheeler.

Along with heavy rain and thunder creating an inconvenience to our Wednesday morning, if you’re headed toward 610 North Loop, you might want to look at an alternative route.

Investigators say it's unclear when the crash scene will clear.

Drivers coming in from Baytown, headed to downtown, look for a different route as an 18-wheeler crash is causing several shutdowns.

An 18-wheeler fire has caused major backups for those traveling on the Katy Freeway.

A crash involving an 18-wheeler has shut down SH-146 at Port Road Thursday, Harris County Sheriff Ed Gonzalez said.

An 18-wheeler was struck after it became stuck on train tracks in Waller County Wednesday, the Waller County Sheriff’s Office said.

A deadly crash involving an 18-wheeler has closed all lanes of the Southwest Freeway outbound near West Sam Houston Parkway.

A pedestrian is dead after being fatally struck by an 18-wheeler in east Houston Tuesday, the Houston Police Department said.

Jeremy Dotson has been training to be a fighter for seven years. On June 12, a traumatic accident sent the MMA athlete to the emergency room, and fighting is what he had to do.

A woman is in critical condition after her vehicle was struck by an 18-wheeler while she was driving the wrong way in northwest Houston Friday, the Houston Police Department said.

A woman is dead after she was possibly struck by an 18-wheeler in Channelview Thursday, Harris County Sheriff’s Office said.

The driver of an 18-wheeler has died after driving off SH-99 at Cypress Rosehill Friday, the Harris County Sheriff’s Office said.

IH-10 Katy eastbound at Patterson Street is back open after a jackknifed 18-wheeler blocked several lanes on Friday, according to TranStar.

A woman had to be extricated from a vehicle after a crash involving a big rig in northeast Houston Thursday, the Houston Police Department said.

A crash involving an 18-wheeler has shut down the 610 South Loop eastbound after Crestmont Wednesday, the Houston Police Department said.

An overturned 18-wheeler is causing major traffic delays on Independence at SH-225, according to the La Porte Office of Emergency Management.

A crash involving an 18-wheeler is the cause of traffic delays happening on IH-610 North Loop eastbound at IH-45 North Friday, according to TranStar.

An overturned 18-wheeler possibly leaking battery acid has shut down several roads in La Porte Thursday, emergency officials said.

One person has died in a crash involving an 18-wheeler and another vehicle Wednesday, the Houston Police Department said.

A lost load from a big rig has shut down the northbound lanes of the North Freeway at I-10 Friday, officers with the Houston Police Department said.

A crash involving two 18-wheelers has shut down I-45 southbound at Shepherd Hill near Montgomery County Monday, the authorities with the Department of Public Safety said.

All the northbound lanes on Southwest Freeway near Highway 288 are back open Tuesday after a crash involving a big rig, officers with the Houston Police Department said.

An investigation is underway after a deadly crash involving an 18-wheeler in northwest Harris County Tuesday, Harris County sheriff’s deputies said.

All mainlanes on I-45 North Freeway outbound at Lake Woodlands are shut down following an 18-wheeler crash in Montgomery County Tuesday, TranStar reported.

An 18-wheeler involved in a rollover crash is blocking the East Freeway inbound and Beltway 8 in east Houston, police said Monday.

An 18-wheeler carrying close to 40,000 pounds of pineapples crashed after one of the tires on the truck blew out in Montgomery County Tuesday, authorities said.

Drivers are currently experiencing traffic delays after an 18-wheeler hit a bridge on the East Freeway Wednesday.

A cleanup is underway after an 18-wheeler carrying fruit overturned in north Harris County Sunday, Precinct 4 deputies said.

An overturned 18-wheeler caused a closure on the Southwest Freeway at Westpark Drive Friday, according to Transtar.

A bicyclist is dead after being struck by an 18-wheeler in Kingwood Wednesday, police said.

An overturned 18-wheeler on Highway 290 near Hollister is blocking several outbound lanes.

A man is dead after the train he was on hit an 18-wheeler in east Harris County, deputies said.

Police said a woman is dead after a police chase involving a man that stole a big rig and crashed into a home in north Harris County on Tuesday.

Police said the right lane and center lanes of Katy Freeway inbound at Patterson are shut down for several hours following an 18-wheeler crash Tuesday morning.

Officials are working to put out an 18-wheeler fire on IH-610 East Loop near Market Street Monday.

The driver of an 18-wheeler was rescued after the big rig overturned in north Houston Wednesday, police said.

Police are investigating after a deadly crash involving an 18-wheeler in southwest Houston Sunday, officers said. Investigators said the crash was caused by a wrong-way driver and two people are dead.

Harris County sheriff’s deputies are investigating a crash involving an 18-wheeler that left a man dead in Deer Park, authorities said.

A man is dead and a 5-year-old boy is in critical condition after the car they were in slammed into the back of an 18-wheeler in Montgomery County Wednesday, deputies said.

Authorities are working to clear up a five-vehicle crash involving an 18-wheeler at the South Loop near SH 225.

The main lanes of US-59 southbound at SH-288 are back open Friday afternoon.

THE WOODLANDS, Texas – First responders are calling this wreck a miracle after an 18-wheeler crossed several lanes of traffic and crashed into a restaurant Tuesday. Firefighters with Montgomery County said the crash happened at a Pappas Bar-B-Q Restaurant off the North Freeway near Woodson Road in The Woodlands around 7 p.m. According to authorities, a vehicle hit the truck’s trailer, causing it to lose control. It then crossed four lanes on the feeder road and hit a restaurant, first responders said. Firefighters said both drivers suffered minor injuries and employees were inside the restaurant at the time but none of them were hurt.